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24
Years of Experience
5,000+
Successful Surgeries
50+
Published Scientific Papers

About Dr. Kamran Aghayev

Dr. Kamran Aghayev, MD, is an internationally recognized neurosurgeon with over 20 years of experience. He’s an Associate Professor of Neurosurgery, practicing in Istanbul, Turkey. With extensive surgical expertise honed in the USA, Dr. Aghayev has established himself as a leading figure in the neurosurgical field, standing at the forefront of the most complex brain and spine procedures. His commitment is to provide exceptional care and deliver optimal outcomes for his patients.

Expertise and Specializations

Dr. Aghayev specializes in a wide range of complex brain and spine conditions. Patients often seek his expertise for:

  • Brain Diseases: including brain tumors, hydrocephalus, brain AVM, pituitary adenoma, and hemifacial spasm.
  • Spine Diseases: including herniated discs, scoliosis, kyphosis, spinal tumors, and failed back surgery syndrome.
  • Specific syndromes such as Thoracic Outlet Syndrome.

 

Learn more about these and other conditions in our ‘Diseases’ section.

Multilingual Abilities

Fluent in multiple languages, including English, Turkish, Azerbaijani, and Russian, Dr. Aghayev effectively communicates with patients from various countries. This linguistic proficiency ensures clear discussions about their conditions and treatment options.

Education and Training

A summa cum laude graduate from Azerbaijan Medical University in 2001, Dr. Aghayev completed his residency in neurological surgery at Hacettepe School of Medicine, Ankara, Turkey, and later undertook a Spinal Oncology Clinical Fellowship at H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida, USA.

Comprehensive and Personalized Care

Dr. Aghayev provides comprehensive and personalized care to a diverse range of patients. Each patient’s condition is unique and requires a tailored approach. His extensive knowledge and expertise ensure that every patient receives the highest level of care and attention.

Contributions to Neurosurgery and Innovations

Innovation is a significant part of Dr. Aghayev’s work. He has developed several unique surgical techniques, including the revolutionary Posterior Upper Rib Excision & Decompression (PURED) technique for the surgical treatment of Thoracic Outlet Syndrome (TOS).

The Best Choice for Expert Neurosurgical Care

For those in search of an expert neurosurgeon in Turkey, Dr. Kamran Aghayev is an outstanding choice. His exceptional skills, vast experience, and dedication to patient care guarantee the highest standard of neurosurgical treatment. Dr. Aghayev’s commitment is always towards improving patients’ quality of life.

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Experience

  • Private Practice
    Neurosurgeon, 2020 – Present
  • Biruni University, Istanbul, Turkey
    Chairman, Department of Neurosurgery, 2017 – 2020
  • Irmet Hospital, Cerkezkoy, Turkey
    Attending Neurosurgeon, 2015 – 2016
  • University of South Florida, Tampa, Florida, USA
    Clinical Instructor of Neurosurgery, H. Lee Moffitt Cancer Center, 2012 – 2015
    Neuro-Oncology Fellow, H. Lee Moffitt Cancer Center, 2011 – 2012
    Spinal Oncology Fellow, H. Lee Moffitt Cancer Center, 2010 – 2011
  • Central Clinic Hospital, Baku, Azerbaijan
    Attending Neurosurgeon, 2009 – 2010
  • Hacettepe University School of Medicine
    Neurosurgery Residency, Department of Neurosurgery, 2002 – 2009
  • Azerbaijan Medical University
    Intern, Neurological Surgery, 2001 – 2002

Granted U.S. Patents

Dr. Kamran Aghayev is a named inventor on 13 granted U.S. patents across three medical-device invention families.

  1. Bone fusion system — 7 U.S. patents granted between 2017 and 2026.
    https://patents.google.com/patent/US12551254B2/en
  2. Transdiscal screw system — 3 U.S. patents granted between 2019 and 2024.
    https://patents.google.com/patent/US12178486B2/en
  3. Expandable intervertebral cage — 3 U.S. patents granted between 2019 and 2024.
    https://patents.google.com/patent/US12156818B2/en

Books

  1. Aghayev, K., Vrionis, F. Diseases of the Spinal Cord: Novel Imaging, Diagnosis, Treatment.
    Chapter: “Intramedullary Spinal Cord Tumors.” 2015.
    https://doi.org/10.1007/978-3-642-54209-1_18
  2. Berker, M., Aghayev, K. Emergent Neurosurgery.
    Chapter: “Brain Trauma.” Hacettepe University Press, Ankara, Turkey. 2010.
    https://www.hacettepetas.com.tr/acil-norosirurji-urun1704.html
  3. Jain, G.P., Aghayev, K.V., Vrionis, F.D. Head and Neck Surgery.
    Chapter: “Anterior Skull Base Tumors.”
  4. Vrionis, F.D., Aghayev, K.V., Gardner, G., Robertson, J.H., Brodkey, J.A.
    Schmidek and Sweet’s Operative Neurosurgical Techniques: Indications, Methods, and Results, Sixth Edition.
    Chapter: “Transtemporal Approaches to Posterior Cranial Fossa.” 2012.
    https://doi.org/10.1016/B978-1-4160-6839-6.10047-4

Scientific Studies

Peer-reviewed Journal Articles

For a comprehensive list of publications, please visit Dr. Kamran Aghayev’s Google Scholar profile.

  1. Aghayev K., Comella Z., Vrionis F.D., Internal carotid artery anterior transposition for internal jugular vein decompression: illustrative case. Journal of Neurosurgery: Case Lessons, 2026;12(9). https://doi.org/10.3171/CASE26599
  2. Dhar U.K., Aghayev K., Sultan H., Rajendran S., Tsai C.T., Vrionis F.D., Finite Element Analysis of Biomechanical Assessment: Traditional Bilateral Pedicle Screw System vs. Novel Reverse Transdiscal Screw System for Lumbar Degenerative Disc Disease. Bioengineering, 2025;12(6):671. https://doi.org/10.3390/bioengineering12060671
  3. Dhar U.K., Sultan H., Aghayev K., Tsai C.T., Vrionis F.D., Biomechanical assessment of anterior plate system, bilateral pedicle screw and transdiscal screw system for high-grade spondylolisthesis: a finite element study. Frontiers in Bioengineering and Biotechnology, 2024;12:1491420. https://doi.org/10.3389/fbioe.2024.1491420
  4. Dhar U.K., Menzer E.L., Lin M., O’Connor T., Ghimire N., Dakwar E., Papanastassiou I.D., Aghayev K., Tsai C.T., Vrionis F.D., Open laminectomy vs. minimally invasive laminectomy for lumbar spinal stenosis: a review. Frontiers in Surgery, 2024;11:1357897. https://doi.org/10.3389/fsurg.2024.1357897
  5. Aghayev K., Dhar U.K., Tsai C.T., Ahmedov M., Vrionis F.D., Sacrolumbar Interbody Fusion (SLIF): Feasibility, Technical Nuances, Biomechanical Assessment, and Clinical Outcomes. Spine Surgery and Related Research, 2024;8(4):448-457. https://doi.org/10.22603/ssrr.2023-0240
  6. Ozdol C., Ozdol N.C., Aghayev K., Underwater versus Closed Drainage System for Surgical Treatment of Chronic Subdural Hematoma. World Neurosurgery, 2024;185:e963-e968. https://doi.org/10.1016/j.wneu.2024.03.004
  7. Tanoren B., Dipcin B., Birdogan S., Unlu M.B., Ozdol C., Aghayev K., Examination of annulus fibrosus and nucleus pulposus in cervical and lumbar intervertebral disc herniation patients by scanning acoustic microscopy, scanning electron microscopy and energy dispersive spectroscopy. RSC Advances, 2024;14:2603-2609. https://doi.org/10.1039/D3RA07195B
  8. Doulgeris J., Lin M., Lee W., Aghayev K., Papanastassiou I.D., Tsai C.T., Vrionis F.D., Inter-Specimen Analysis of Diverse Finite Element Models of the Lumbar Spine. Bioengineering, 2024;11(1):24. https://doi.org/10.3390/bioengineering11010024
  9. Aghayev K., Safety and Efficacy of Posterior Upper Rib Excision and Decompression Technique for Surgical Treatment of Neurogenic Thoracic Outlet Syndrome. World Neurosurgery, 2023;180:e739-e748. https://doi.org/10.1016/j.wneu.2023.10.017
  10. Akaslan I., Ertas A., Uzel M., Ozdol C., Aghayev K., Surgical Anatomy of the Posterior Intermuscular Approach to the Brachial Plexus. Hand, 2021;16(6):759-764. https://doi.org/10.1177/1558944719895619
  11. Aghayev K., Iqbal S.M.A., Asghar W., Shahmurzada B., Vrionis F.D., Advances in CSF shunt devices and their assessment for the treatment of hydrocephalus. Expert Review of Medical Devices, 2021;18(9):865-873. https://doi.org/10.1080/17434440.2021.1962289
  12. Rahimli T., Hidayetov T., Yusifli Z., Memmedzade H., Rajabov T., Aghayev K., Endoscopic endonasal approach to giant pituitary adenomas: Surgical outcomes and review of the literature. World Neurosurgery, 2021. https://doi.org/10.1016/j.wneu.2021.01.019
  13. Ertas A., Gediz T., Ozdol C., Gurses I.A., Onder M., Uzel M., Aghayev K., Risk of intervertebral disc joint puncture during lumbar puncture. Clinical Neurology and Neurosurgery, 2021. https://doi.org/10.1016/j.clineuro.2020.106107
  14. Aghayev K., Surgically treated epilepsy due to developmental venous anomaly of the brain: case report and review of the literature. World Neurosurgery, 2020. https://doi.org/10.1016/j.wneu.2020.06.040
  15. Ozdol C., Kulaksizoglu S., Uyar R., Gediz T., Aghayev K., Initial Results of Using Blood Beta 2 Transferrin as a Marker of the Functional Status of a Shunt. World Neurosurgery, 2019. https://doi.org/10.1016/j.wneu.2019.04.185
  16. Ozdol C., Gediz T., Basak A.T., Basak N., Aghayev K., Shunt Tapping Versus Lumbar Puncture for Evaluating Cerebrospinal Fluid Infections in a Pediatric Population. Turkish Neurosurgery, 2019. https://doi.org/10.5137/1019-5149.JTN.24714-18.1
  17. Ozdol C., Gediz T., Aghayev K., Cranial and spinal injuries in motorcycle accidents: A hospital-based study. Ulusal Travma ve Acil Cerrahi Dergisi, 2019. https://doi.org/10.14744/tjtes.2019.46116
  18. Ozdol C., Aghayev K., U-shaped Dural Flap: A Simple Method for Transcranial Skull Base Defect Repair-Technical Report. Journal of Neurological Surgery Part A: Central European Neurosurgery, 2019. https://doi.org/10.1055/s-0039-1688558
  19. Bilen B., Ates Alkan F., Barutcu U.B., Sezen M., Unlu M.B., Aghayev K., Examination of metal mobilization from a gunshot by scanning acoustic microscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and inductively coupled plasma optical emission spectroscopy: a case report. Journal of Medical Case Reports, 2018. https://doi.org/10.1186/s13256-018-1905-7
  20. Aghayev K., Ciklatekerlio O., Posterior Upper Rib Excision for Neurogenic Thoracic Outlet Syndrome—Feasibility and Early Outcomes. Operative Neurosurgery, 2018;14(5):532-537. https://doi.org/10.1093/ons/opx143
  21. Filis A.K., Aghayev K., Vrionis F.D., Cerebrospinal Fluid and Hydrocephalus: Physiology, Diagnosis, and Treatment. Cancer Control, 2017. https://doi.org/10.1177/107327481702400102
  22. Filis A.K., Aghayev K., Schaller B., Luksza J., Vrionis F.D., Transdiscal mid- and upper thoracic vertebroplasty: first description of 2 exemplary cases. Journal of Neurosurgery: Spine, 2016. https://doi.org/10.3171/2015.12.SPINE15946
  23. Shea T.M., Doulgeris J.J., Gonzalez-Blohm S.A., Lee W.E. 3rd, Aghayev K., Vrionis F.D., Balancing rigidity and safety of pedicle screw fixation via a novel expansion mechanism in a severely osteoporotic model. BioMed Research International, 2015. https://doi.org/10.1155/2015/318405
  24. Gonzalez-Blohm S.A., Doulgeris J.J., Lee W.E. 3rd, Shea T.M., Aghayev K., Vrionis F.D., The current testing protocols for biomechanical evaluation of lumbar spinal implants in laboratory setting: a review of the literature. BioMed Research International, 2015. https://doi.org/10.1155/2015/506181
  25. Doulgeris J.J., Gonzalez-Blohm S.A., Filis A.K., Shea T.M., Aghayev K., Vrionis F.D., Robotics in Neurosurgery: Evolution, Current Challenges, and Compromises. Cancer Control, 2015. https://doi.org/10.1177/107327481502200314
  26. Doulgeris J.J., Aghayev K., Gonzalez-Blohm S.A., Lee W.E. 3rd, Vrionis F.D., Biomechanical comparison of an interspinous fusion device and bilateral pedicle screw system as additional fixation for lateral lumbar interbody fusion. Clinical Biomechanics, 2015. https://doi.org/10.1016/j.clinbiomech.2014.10.003
  27. Shea T.M., Laun J., Gonzalez-Blohm S.A., Doulgeris J.J., Lee W.E., Aghayev K., Vrionis F.D., Designs and techniques that improve the pullout strength of pedicle screws in osteoporotic vertebrae: current status. BioMed Research International, 2014. https://doi.org/10.1155/2014/748393
  28. Papanastassiou I.D., Filis A., Aghayev K., Kokkalis Z.T., Gerochristou M.A., Vrionis F.D., Adverse prognostic factors and optimal intervention time for kyphoplasty/vertebroplasty in osteoporotic fractures. BioMed Research International, 2014. https://doi.org/10.1155/2014/925683
  29. Gonzalez-Blohm S.A., Doulgeris J.J., Aghayev K., Lee W.E. 3rd, Volkov A., Vrionis F.D., Biomechanical analysis of an interspinous fusion device as a stand-alone and as supplemental fixation to posterior expandable interbody cages in the lumbar spine. Journal of Neurosurgery: Spine, 2014. https://doi.org/10.3171/2013.10.SPINE13612
  30. Gonzalez-Blohm S.A., Doulgeris J.J., Aghayev K., Lee W.E. 3rd, Laun J., Vrionis F.D., In vitro evaluation of a lateral expandable cage and its comparison with a static device for lumbar interbody fusion: a biomechanical investigation. Journal of Neurosurgery: Spine, 2014. https://doi.org/10.3171/2013.12.SPINE13798
  31. Filis A.K., Aghayev K.V., Doulgeris J.J., Gonzalez-Blohm S.A., Vrionis F.D., Spinal neoplastic instability: biomechanics and current management options. Cancer Control, 2014. https://doi.org/10.1177/107327481402100207
  32. Doulgeris J.J., Gonzalez-Blohm S.A., Aghayev K., Shea T.M., Lee W.E. 3rd, Hess D.P., Vrionis F.D., Axial rotation mechanics in a cadaveric lumbar spine model: a biomechanical analysis. The Spine Journal, 2014. https://doi.org/10.1016/j.spinee.2013.11.037
  33. Aghayev K., Gonzalez-Blohm S.A., Doulgeris J.J., Lee W.E. 3rd, Waddell J.K., Vrionis F.D., Feasibility and biomechanical performance of a novel transdiscal screw system for one level in non-spondylolisthetic lumbar fusion: an in vitro investigation. The Spine Journal, 2014. https://doi.org/10.1016/j.spinee.2013.08.033
  34. Aghayev K., Doulgeris J.J., Gonzalez-Blohm S.A., Eleraky M., Lee W.E. 3rd, Vrionis F.D., Biomechanical comparison of a two-level anterior discectomy and a one-level corpectomy, combined with fusion and anterior plate reconstruction in the cervical spine. Clinical Biomechanics, 2014. https://doi.org/10.1016/j.clinbiomech.2013.10.016
  35. Aghayev K., Vrionis F.D., Mini-open lateral retroperitoneal lumbar spine approach using psoas muscle retraction technique. Technical report and initial results on six patients. European Spine Journal, 2013;22(9):2113-2119. https://doi.org/10.1007/s00586-013-2931-1
  36. Papanastassiou I.D., Gerochristou M., Aghayev K., Vrionis F.D., Defining the indications, types and biomaterials of corpectomy cages in the thoracolumbar spine. Expert Review of Medical Devices, 2013. https://doi.org/10.1586/erd.12.79
  37. Doulgeris J.J., Aghayev K., Gonzalez-Blohm S.A., Del Valle M., Waddell J., Lee W.E. 3rd, Vrionis F.D., Comparative analysis of posterior fusion constructs as treatments for middle and posterior column injuries: an in vitro biomechanical investigation. Clinical Biomechanics, 2013. https://doi.org/10.1016/j.clinbiomech.2013.05.001
  38. Berker M., Aghayev K., Yucel T., Hazer D.B., Onerci M., Management of cerebrospinal fluid leak during endoscopic pituitary surgery. Auris Nasus Larynx, 2013. https://doi.org/10.1016/j.anl.2012.11.006
  39. Papanastassiou I.D., Phillips F.M., Van Meirhaeghe J., Berenson J.R., Andersson G.B.J., Chung G., Small B.J., Aghayev K., Vrionis F.D., Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies. European Spine Journal, 2012;21(9):1826-1843. https://doi.org/10.1007/s00586-012-2314-z
  40. Papanastassiou I.D., Aghayev K., Saleh E., Gerochristou M., Vrionis F.D., The actual management of tumor and vertebral compression fractures. Journal of Neurosurgical Sciences, 2012;56(2):77-85. PubMed
  41. Papanastassiou I.D., Aghayev K., Berenson J.R., Schmidt M.H., Vrionis F.D., Is vertebral augmentation the right choice for cancer patients with painful vertebral compression fractures? Journal of the National Comprehensive Cancer Network, 2012. https://doi.org/10.6004/jnccn.2012.0074
  42. Setzer M., Eleraky M., Johnson W.M., Aghayev K., Tran N.D., Vrionis F.D., Biomechanical comparison of anterior cervical spine instrumentation techniques with and without supplemental posterior fusion after different corpectomy and discectomy combinations. Journal of Neurosurgery: Spine, 2012;16(6):579-584. https://doi.org/10.3171/2012.2.SPINE11611
  43. Aghayev K., Bal E., Rahimli T., Mut M., Balci S., Vrionis F., Akalan N., Aquaporin-4 expression is not elevated in mild hydrocephalus. Acta Neurochirurgica, 2012. https://doi.org/10.1007/s00701-011-1241-9
  44. Aghayev K., Vrionis F., Chamberlain M.C., Adult intradural primary spinal cord tumors. Journal of the National Comprehensive Cancer Network, 2011. https://doi.org/10.6004/jnccn.2011.0039
  45. Aghayev K., Papanastassiou I.D., Vrionis F., Role of vertebral augmentation procedures in the management of vertebral compression fractures in cancer patients. Current Opinion in Supportive and Palliative Care, 2011. https://doi.org/10.1097/SPC.0b013e328349652d
  46. Aghayev K., Bal E., Rahimli T., et al., Expression of water channel aquaporin-4 during experimental syringomyelia: laboratory investigation. Journal of Neurosurgery: Spine, 2011;15(4):428-432. https://doi.org/10.3171/2011.5.SPINE10303
  47. Berker M., Aghayev K., Saatci I., Palaoglu S., Onerci M., Overview of vascular complications of pituitary surgery with special emphasis on unexpected abnormality. Pituitary, 2010;13(2):160-167. https://doi.org/10.1007/s11102-009-0198-7
  48. Bilginer B., Yavuz K., Agayev K., Akbay A., Ziyal I.M., Existence of cotton granuloma after removal of a parasagittal meningioma: clinical and radiological evaluation—a case report. Kobe Journal of Medical Sciences, 2007. [pdf]
  49. Aghayev K., Onal B., Yavuz K., Ziyal M., The Association of A1 Segment Hypoplasia/Aplasia with Anterior Communicating Artery Aneurysms: A Radiological Study. Turkish Neurosurgery, 2005. [pdf]

Conference Contributions

  1. Comella Z., Aghayev K., Demir H., Ozdol C., Vrionis F.D., Beyond Styloidectomy: A Novel Circumferential Approach to Treating Atlanto-Styloid Compression Syndrome. Baptist Health Academic Conference: The Art and Science of Interprofessional Collaborations, 2026.
  2. Toloza E., Rodriguez K., Velez-Cubian F., Zhang W.W., Thau M., Moodie C., Garrett J., Aghayev K., Fontaine J., Robinson L., Vrionis F.D., Feasibility of Hybrid Robotic-Assisted Pulmonary Lobectomy With En Bloc Chest Wall Resection and Reconstruction. CHEST, 2014;146(4 Suppl):89A. https://doi.org/10.1378/chest.1995241
  3. Papanastassiou I.D., Phillips F.M., Van Meirhaeghe J., Andersson G.B.J., Berenson J.R., Chung G., Small B.J., El Eraky M., Aghayev K., Vrionis F.D., Comparison of Kyphoplasty, Vertebroplasty, and Nonsurgical Management in a Meta-Analysis of Randomized and Nonrandomized Controlled Studies. The Spine Journal, 2011;11(10 Suppl):S37-S38. https://doi.org/10.1016/j.spinee.2011.08.100
  4. Papanastassiou I.D., El Eraky M., Aghayev K., Vrionis F.D., Comparison of Unilateral Versus Bilateral Kyphoplasty in Cancer-Related Vertebral Fractures. The Spine Journal, 2011;11(10 Suppl):S8. https://doi.org/10.1016/j.spinee.2011.08.029